Francisco Comesana

In May 2022, Comesaña won his first ATP Challenger doubles title in Vicenza, partnering Luciano Darderi. The following month, he won back-to-back singles titles at the Corrientes Challenger and the Challenger Tenis Club Argentino, both in his home country and both against Mariano Navone in the final.

In May 2023, he reached the final of the Macedonian Open, but lost to Máté Valkusz. The following week, he won the Internazionali di Tennis Città di Vicenza, defeating Pablo Llamas Ruiz in the final. Later that year, he won his fourth Challenger title at the Svijany Open and reached the final of the Santa Cruz Challenger.

In February 2024, Comesaña made his ATP debut at the Córdoba Open as a wildcard, but lost to compatriot and lucky loser Thiago Agustín Tirante in the first round. He qualified for his first ATP 500 tournament at the Rio Open, but lost to fourth seed and compatriot Francisco Cerúndolo in the first round. He entered the Chile Open as a lucky loser, but lost to Juan Pablo Varillas in the first round. After winning the Challenger title at the Open de Oeiras, he reached the top 100 for the first time on 22 April 2024.

Ranked No. 122, Comesaña made his Grand Slam tournament debut at Wimbledon and upset sixth seed Andrey Rublev in the first round in only his second match on grass ever. This was his first win at the ATP level, his first win at a Major, and his first win over a top 10 player. He then defeated Adam Walton to reach the third round. He lost to 25th seed Lorenzo Musetti in four sets.

On his debut at the US Open, he reached again the third round of a Grand Slam, defeating Dominic Stricker in the first round, then upsetting 17th-seed Ugo Humbert in the second round. In October, he won his second Challenger title for the season at the 2024 Challenger de Buenos Aires on his 24th birthday.

Ranked No. 86 at the ATP 500 2025 Rio Open, Comesaña recorded his first two ATP wins outside the Majors defeating wildcard Gustavo Heide and sixth seed Nicolás Jarry (after saving a match point) to reach his first ATP Tour quarterfinal. Both matches lasted over 3 hours, the second match featuring three tiebreaks. He then upset world No. 2 and top seed Alexander Zverev in the quarterfinal, his biggest win by ranking, after trailing 1-4 in the final set, to reach his first ATP tour-level semifinal. He lost to Alexandre Müller after playing for almost three hours, including crashing in the net in the second set, in his fourth three-setter of the week.

He made his Masters debut at the 2025 Miami Open as a qualifier but lost to 17 year-old debutant and wildcard Federico Cinà.