Head to Head
| Uruguay Clausura | 2017/11/05 22:00 | Penarol v Defensor Sporting | W | 3-1 |
| Uruguay Torneo Intermedio | 2017/07/08 19:00 | Penarol v Defensor Sporting | L | 2-3 |
| Uruguay Apertura | 2017/03/25 19:30 | Defensor Sporting v Penarol | D | 2-2 |
| Uruguay Apertura | 2016/12/10 20:15 | Penarol v Defensor Sporting | L | 0-2 |
| Uruguay Clausura | 2016/02/21 23:00 | Penarol v Defensor Sporting | W | 5-1 |
| Uruguay Apertura | 2015/08/30 21:00 | Defensor Sporting v Penarol | L | 3-1 |
| Uruguay Clausura | 2015/03/15 20:00 | Penarol v Defensor Sporting | W | 2-0 |
| Uruguay Apertura | 2014/09/06 18:00 | Defensor Sporting v Penarol | D | 0-0 |
Home History
| Uruguay Clausura | 2017/11/19 22:00 | Penarol v Plaza Colonia | W | 3-0 |
| Uruguay Clausura | 2017/11/16 20:00 | Danubio v Penarol | W | 0-2 |
| Uruguay Clausura | 2017/11/11 21:00 | Penarol v Juventud De Las Piedras | W | 1-0 |
| Uruguay Clausura | 2017/11/08 23:00 | IA Sud America v Penarol | W | 2-3 |
| Uruguay Clausura | 2017/11/05 22:00 | Penarol v Defensor Sporting | W | 3-1 |
| Uruguay Clausura | 2017/10/14 21:00 | Rampla Juniors v Penarol | W | 1-4 |
| Uruguay Clausura | 2017/10/07 21:00 | Penarol v Atletico Fenix Montevideo | W | 3-0 |
| Uruguay Clausura | 2017/09/17 19:00 | Nacional De Football v Penarol | W | 0-2 |
Away History
| Uruguay Clausura | 2017/11/19 19:00 | Boston River v Defensor Sporting | W | 0-1 |
| Uruguay Clausura | 2017/11/16 22:30 | Defensor Sporting v Liverpool Montevideo | D | 2-2 |
| Uruguay Clausura | 2017/11/12 22:30 | El Tanque Sisley v Defensor Sporting | W | 0-2 |
| Uruguay Clausura | 2017/11/08 20:00 | Defensor Sporting v Racing Club de Montevideo | W | 4-2 |
| Uruguay Clausura | 2017/11/05 22:00 | Penarol v Defensor Sporting | L | 3-1 |
| Uruguay Clausura | 2017/10/14 18:30 | Defensor Sporting v CA River Plate | W | 2-1 |
| Uruguay Clausura | 2017/10/08 19:30 | Plaza Colonia v Defensor Sporting | W | 1-2 |
| Uruguay Clausura | 2017/09/16 19:00 | Defensor Sporting v Danubio | W | 1-0 |
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